vicissitude
Concise Oxford English Dictionary © 2008 Oxford University Press:
vicissitude /vɪˈsɪsɪtjuːd, vʌɪ-/
▶noun
- 1 a change of circumstances or fortune, typically for the worse.
- 2 literary alternation between contrasting things.
– derivatives
vicissitudinous /-ˈtjuːdɪnəs/ adjective.
vicissitudinous /-ˈtjuːdɪnəs/ adjective.
– origin C17: from Fr., or from L. vicissitudo, from vicissim ‘by turns’, from vic- ‘turn, change’.
'vicissitude' also found in these Oxford entries:

