WordReference English-French Dictionary © 2014:

Principal Translations/Principales traductions
in vain advadverb: Describes a verb, adjective, adverb, or clause--for example, "come quickly," "very rare," "happening now," "fall down." (pointlessly, for nothing)en vain advadverbe: modifie un adjectif ou un verbe. Est toujours invariable ! Ex : "Elle est très grande." "Je marche lentement."
 She tried in vain to open the door but it was useless.
 Elle a tenté en vain d'ouvrir la porte, mais c'était inutile.
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