WordReference English-Spanish Dictionary © 2019:

Principal Translations
SpanishEnglish
agotar la paciencia de alguien,
agotarle la paciencia a alguien
loc verblocución verbal: Unidad léxica estable formada de dos o más palabras que funciona como verbo ("sacar fuerzas de flaqueza", "acusar recibo").
(cansar, fastidiar)try [sb]'s patience v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
 Juan siempre agota la paciencia de su padre, es un cansino.
 John is always trying his father's patience; he's so weary.
 
Additional Translations
SpanishEnglish
agotarse la paciencia de alguien loc verblocución verbal: Unidad léxica estable formada de dos o más palabras que funciona como verbo ("sacar fuerzas de flaqueza", "acusar recibo"). (cansarse, fastidiarse)run out of patience v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
  exhaust [sb]'s patience, test [sb]'s patience v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
  (informal)drive [sb] up the wall v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
 Se me está agotando la paciencia contigo, ya no te lo vuelvo a decir.
 I'm running out of patience with you and I won't tell you again!
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