WordReference English-Spanish Dictionary © 2014:

Principal Translations
despegar vtrverbo transitivo: Verbo que requiere de un objeto directo ("di la verdad", "encontré una moneda"). (desprender, soltar)remove, detach vtrtransitive verb: Verb taking a direct object--for example, "Say something." "She found the cat."
  take off vtr phrasal sepphrasal verb, transitive, separable: Verb with adverb(s) or preposition(s), having special meaning, divisible--for example, "call off" [=cancel], "call the game off," "call off the game."
  unstick, unglue vtrtransitive verb: Verb taking a direct object--for example, "Say something." "She found the cat."
 Despega la etiqueta del frasco sin romperla.
 Remove (or: detach) the label from the bottle without tearing it.
despegar viverbo intransitivo: Verbo que no requiere de un objecto directo (Él no llegó", "corrí a casa"). (vehículo aéreo: elevarse)take off vi phrasalphrasal verb, intransitive: Verb with adverb(s) or preposition(s), having special meaning and not taking direct object--for example, "make up" [=reconcile]: "After they fought, they made up."
   (rocket)lift off, blast off vi phrasal insep
 El avión no despegó debido a las adversas condiciones meteorológicas.
 The aircraft did not take off because of the adverse weather conditions.
 
Additional Translations
despegar viverbo intransitivo: Verbo que no requiere de un objecto directo (Él no llegó", "corrí a casa"). (negocio: iniciar el éxito)  (figurative)take off viintransitive verb: Verb not taking a direct object--for example, "She jokes." "He has arrived."
   (figurative)get off the ground v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
 Es necesario inyectar capital a un negocio para lograr que despegue.
 Capital has to be injected into a business to help it take off.
despegarse v prnlverbo pronominal: Verbo que se conjuga con un pronombre átono ("me", "te", "se") que concuerda con el sujeto ("lavarse", "irse", "enojarse"). figurado (apartarse, separarse)leave vtrtransitive verb: Verb taking a direct object--for example, "Say something." "She found the cat."
  be separated from v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
 No se despega de su madre ni un segundo; es un niño muy tímido.
 He won't leave his mother for a second. He's a very timid child.
despegarse v prnlverbo pronominal: Verbo que se conjuga con un pronombre átono ("me", "te", "se") que concuerda con el sujeto ("lavarse", "irse", "enojarse"). (desprenderse)  (separate)come off viintransitive verb: Verb not taking a direct object--for example, "She jokes." "He has arrived."
   (multiple pieces)come apart viintransitive verb: Verb not taking a direct object--for example, "She jokes." "He has arrived."
   (literary)come undone viintransitive verb: Verb not taking a direct object--for example, "She jokes." "He has arrived."
   (glue)come unglued viintransitive verb: Verb not taking a direct object--for example, "She jokes." "He has arrived."
 Se despegó la tapa de mi libro.
 The cover of my book came off.
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