WordReference English-Spanish Dictionary © 2014:

Principal Translations
despreciar vtrverbo transitivo: Verbo que requiere de un objeto directo ("di la verdad", "encontré una moneda"). (no considerar algo)disregard, ignore, pay no attention to v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
   (attach little value to)discount vtrtransitive verb: Verb taking a direct object--for example, "Say something." "She found the cat."
   (offer)spurn vtrtransitive verb: Verb taking a direct object--for example, "Say something." "She found the cat."
   (formal)pay no heed to v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
 Despreció el consejo de su amigo y actuó de forma irresponsable.
 He paid no attention to his friend's advice, and acted irresponsibly.
despreciar vtrverbo transitivo: Verbo que requiere de un objeto directo ("di la verdad", "encontré una moneda"). (menoscabar a alguien)look down on v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
   (informal)look down your nose at v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
   (have contempt)despise, scorn vi + prep
   (express contempt)sneer at, put down v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
 Desprecia a su vecino y se lo hace saber siempre que puede.
 She looks down on her neighbor, and lets her know it every chance she gets.
 
Additional Translations
despreciarse v prnlverbo pronominal: Verbo que se conjuga con un pronombre átono ("me", "te", "se") que concuerda con el sujeto ("lavarse", "irse", "enojarse"). (asquearse de uno mismo)be disgusted with yourself v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
  despise yourself, vtr + refltransitive verb and reflexive pronoun: Transitive verb with reflexive pronoun--for example, "Enjoy yourself." "They behaved themselves."
 Se despreciaba por actuar así, pero no sabía evitarlo.
 She was disgusted with herself for acting that way, but she didn't know how to stop it.
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