WordReference English-Spanish Dictionary © 2015:

Principal Translations
despreciar vtrverbo transitivo: Verbo que requiere de un objeto directo ("di la verdad", "encontré una moneda"). (no considerar algo)disregard, discount vtrtransitive verb: Verb taking a direct object--for example, "Say something." "She found the cat."
  pay no attention to v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
  (offer)spurn vtrtransitive verb: Verb taking a direct object--for example, "Say something." "She found the cat."
  (formal)pay no heed to v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
 Despreció el consejo de su amigo y actuó de forma irresponsable.
 He disregarded (or: discounted) his friend's advice, and acted irresponsibly.
despreciar vtrverbo transitivo: Verbo que requiere de un objeto directo ("di la verdad", "encontré una moneda"). (menoscabar a alguien)look down on v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
  (informal)look down your nose at v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
  (have contempt)despise, scorn vtrtransitive verb: Verb taking a direct object--for example, "Say something." "She found the cat."
  (express contempt)put down vtr phrasal sepphrasal verb, transitive, separable: Verb with adverb(s) or preposition(s), having special meaning, divisible--for example, "call off" [=cancel], "call the game off," "call off the game."
 Desprecia a su vecino y se lo hace saber siempre que puede.
 She looks down on her neighbor, and lets her know it every chance she gets.
 
Additional Translations
despreciarse v prnlverbo pronominal: Verbo que se conjuga con un pronombre átono ("me", "te", "se") que concuerda con el sujeto ("lavarse", "irse", "enojarse"). (asquearse de uno mismo)be disgusted with yourself v exprverbal expression: Phrase with special meaning functioning as verb--for example, "put their heads together," "come to an end."
  despise yourself vtr + pron
 Se despreciaba por actuar así, pero no sabía evitarlo.
 She was disgusted with herself for acting that way, but she didn't know how to stop it.
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